Weight Management
Mfg : Granules PharmaceuticalsMetformin HCL ER
Metformin supports weight management by lowering blood glucose through AMPK activation while enhancing insulin sensitivity.
Insulin Function: Reduces glucose production and enhances insulin sensitivity, addressing insulin resistance linked to obesity.
Weight Loss Support: Alters gut microbiota, reduces calorie absorption, and supports appetite suppression via GLP-1.
Metabolic Enhancement: AMPK activation promotes cellular energy efficiency for modest, sustainable weight reduction.
Maximum Doses: 4
Per Dose $ 00.00
Total Price
Metformin ER works by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues. Clinical studies demonstrate A1C reduction of 1-2% in diabetes patients, with potential weight-neutral or modest weight-loss effects (2-4 kg average) compared to other diabetes medications that promote weight gain.
The ER formulation features: once-daily dosing convenience reduced peak plasma concentrations (?GI side effects) similar glycemic control to immediate-release with fewer doses and gastric-retentive delivery system that slowly releases medication over 24 hours. Typical starting dose is 500mg nightly, titrated weekly up to maximum 2000mg daily.
While mechanisms arent fully understood, metformin may support weight management through: reduced insulin resistance (?fat storage signaling) mild appetite suppression potential modulation of gut microbiome and decreased carbohydrate absorption. Effects are typically modest (3-5% body weight over 6-12 months) and most pronounced in insulin-resistant individuals.
Common side effects include GI disturbances (20-30%), which are typically transient. Rare but serious risks include lactic acidosis (warning signs: malaise, myalgias, respiratory distress). Contraindicated in severe renal impairment (eGFR <30), metabolic acidosis, or advanced liver disease. Requires dose adjustment for eGFR 30-45.
Take with evening meal to minimize GI effects avoid excessive alcohol monitor vitamin B12 levels with long-term use temporary discontinuation may be needed before iodinated contrast procedures. Not a substitute for diet/exercise but rather an adjunct to lifestyle modification.
