Vardenafil HCL

Rapid Onset of Action

Vardenafil begins working faster than sildenafil for many patients, with some men experiencing effects in as little as 25 minutes. Peak plasma concentrations occur within 0.5-2 hours post-dose. The medication remains effective for 4-5 hours, providing a balanced window of opportunity without the extended duration of tadalafil.

Dosing Information

Available in 5mg, 10mg, and 20mg tablets. The recommended starting dose is 10mg taken 25-60 minutes before sexual activity, adjusted based on efficacy and tolerability. Maximum dosing frequency is once daily. The orally disintegrating tablet (ODT) formulation can be taken without water.

Clinical Effectiveness

In clinical trials, vardenafil improved erectile function in 76% of men (vs 23% placebo) with various ED causes. Success rates were consistent across age groups and ED severities. The medication works synergistically with sexual stimulation - it does not automatically produce erections.

Safety Considerations

Common side effects include headache (15%), flushing (11%), nasal congestion (9%), and dyspepsia (4%). Contraindicated with nitrates or guanylate cyclase stimulators due to hypotension risk. Use caution with alpha-blockers, CYP3A4 inhibitors, or cardiovascular conditions. Not recommended in severe hepatic impairment.

Optimal Usage Tips

Take on empty stomach for fastest absorption (high-fat meals may delay onset). Avoid excessive alcohol consumption. The ODT formulation should be placed on the tongue without water - effects may begin within 15 minutes. Store tablets at room temperature away from moisture.